diff --git a/modules/openapi-generator/src/main/resources/python/configuration.mustache b/modules/openapi-generator/src/main/resources/python/configuration.mustache
index 6581e603ad5..7fdcd894277 100644
--- a/modules/openapi-generator/src/main/resources/python/configuration.mustache
+++ b/modules/openapi-generator/src/main/resources/python/configuration.mustache
@@ -271,6 +271,15 @@ class Configuration(object):
         result.debug = self.debug
         return result
 
+    def __setattr__(self, name, value):
+        object.__setattr__(self, name, value)
+{{#hasHttpSignatureMethods}}
+        if name == "signing_info" and value is not None:
+            # Ensure the host paramater from signing info is the same as
+            # Configuration.host.
+            value.host = self.host
+{{/hasHttpSignatureMethods}}
+
     @classmethod
     def set_default(cls, default):
         """Set default instance of configuration.
diff --git a/samples/client/petstore/python-asyncio/petstore_api/configuration.py b/samples/client/petstore/python-asyncio/petstore_api/configuration.py
index 025188fd17d..ef96f1bc5cd 100644
--- a/samples/client/petstore/python-asyncio/petstore_api/configuration.py
+++ b/samples/client/petstore/python-asyncio/petstore_api/configuration.py
@@ -195,6 +195,9 @@ class Configuration(object):
         result.debug = self.debug
         return result
 
+    def __setattr__(self, name, value):
+        object.__setattr__(self, name, value)
+
     @classmethod
     def set_default(cls, default):
         """Set default instance of configuration.
diff --git a/samples/client/petstore/python-experimental/petstore_api/configuration.py b/samples/client/petstore/python-experimental/petstore_api/configuration.py
index 03ac961e1d2..066665d16fc 100644
--- a/samples/client/petstore/python-experimental/petstore_api/configuration.py
+++ b/samples/client/petstore/python-experimental/petstore_api/configuration.py
@@ -199,6 +199,9 @@ class Configuration(object):
         result.debug = self.debug
         return result
 
+    def __setattr__(self, name, value):
+        object.__setattr__(self, name, value)
+
     @classmethod
     def set_default(cls, default):
         """Set default instance of configuration.
diff --git a/samples/client/petstore/python-tornado/petstore_api/configuration.py b/samples/client/petstore/python-tornado/petstore_api/configuration.py
index 03ac961e1d2..066665d16fc 100644
--- a/samples/client/petstore/python-tornado/petstore_api/configuration.py
+++ b/samples/client/petstore/python-tornado/petstore_api/configuration.py
@@ -199,6 +199,9 @@ class Configuration(object):
         result.debug = self.debug
         return result
 
+    def __setattr__(self, name, value):
+        object.__setattr__(self, name, value)
+
     @classmethod
     def set_default(cls, default):
         """Set default instance of configuration.
diff --git a/samples/client/petstore/python/petstore_api/configuration.py b/samples/client/petstore/python/petstore_api/configuration.py
index 03ac961e1d2..066665d16fc 100644
--- a/samples/client/petstore/python/petstore_api/configuration.py
+++ b/samples/client/petstore/python/petstore_api/configuration.py
@@ -199,6 +199,9 @@ class Configuration(object):
         result.debug = self.debug
         return result
 
+    def __setattr__(self, name, value):
+        object.__setattr__(self, name, value)
+
     @classmethod
     def set_default(cls, default):
         """Set default instance of configuration.
diff --git a/samples/openapi3/client/petstore/python-experimental/petstore_api/configuration.py b/samples/openapi3/client/petstore/python-experimental/petstore_api/configuration.py
index d68709a5d81..d885572339e 100644
--- a/samples/openapi3/client/petstore/python-experimental/petstore_api/configuration.py
+++ b/samples/openapi3/client/petstore/python-experimental/petstore_api/configuration.py
@@ -246,6 +246,13 @@ class Configuration(object):
         result.debug = self.debug
         return result
 
+    def __setattr__(self, name, value):
+        object.__setattr__(self, name, value)
+        if name == "signing_info" and value is not None:
+            # Ensure the host paramater from signing info is the same as
+            # Configuration.host.
+            value.host = self.host
+
     @classmethod
     def set_default(cls, default):
         """Set default instance of configuration.
diff --git a/samples/openapi3/client/petstore/python/petstore_api/configuration.py b/samples/openapi3/client/petstore/python/petstore_api/configuration.py
index 994d4c73fbb..d0d05b11381 100644
--- a/samples/openapi3/client/petstore/python/petstore_api/configuration.py
+++ b/samples/openapi3/client/petstore/python/petstore_api/configuration.py
@@ -199,6 +199,9 @@ class Configuration(object):
         result.debug = self.debug
         return result
 
+    def __setattr__(self, name, value):
+        object.__setattr__(self, name, value)
+
     @classmethod
     def set_default(cls, default):
         """Set default instance of configuration.