diff --git a/modules/openapi-generator/src/main/resources/python/api_client.mustache b/modules/openapi-generator/src/main/resources/python/api_client.mustache
index 95fef884bc1..1c204ad1595 100644
--- a/modules/openapi-generator/src/main/resources/python/api_client.mustache
+++ b/modules/openapi-generator/src/main/resources/python/api_client.mustache
@@ -234,6 +234,9 @@ class ApiClient(object):
         # data needs deserialization or returns HTTP data (deserialized) only
         if _preload_content or _return_http_data_only:
           response_type = response_types_map.get(str(response_data.status), None)
+          if not response_type and type(response_data.status) == int and 100 <= response_data.status <= 599:
+              # if not found, look for '1XX', '2XX', etc.
+              response_type = response_types_map.get(str(response_data.status)[0] + "XX", None)
 
           if response_type == "bytearray":
               response_data.data = response_data.data
diff --git a/samples/client/echo_api/python/openapi_client/api_client.py b/samples/client/echo_api/python/openapi_client/api_client.py
index 1b315709ffe..3f407664d47 100644
--- a/samples/client/echo_api/python/openapi_client/api_client.py
+++ b/samples/client/echo_api/python/openapi_client/api_client.py
@@ -227,6 +227,9 @@ class ApiClient(object):
         # data needs deserialization or returns HTTP data (deserialized) only
         if _preload_content or _return_http_data_only:
           response_type = response_types_map.get(str(response_data.status), None)
+          if not response_type and type(response_data.status) == int and 100 <= response_data.status <= 599:
+              # if not found, look for '1XX', '2XX', etc.
+              response_type = response_types_map.get(str(response_data.status)[0] + "XX", None)
 
           if response_type == "bytearray":
               response_data.data = response_data.data
diff --git a/samples/openapi3/client/petstore/python-aiohttp/petstore_api/api_client.py b/samples/openapi3/client/petstore/python-aiohttp/petstore_api/api_client.py
index daa972358f7..66ae38bf984 100644
--- a/samples/openapi3/client/petstore/python-aiohttp/petstore_api/api_client.py
+++ b/samples/openapi3/client/petstore/python-aiohttp/petstore_api/api_client.py
@@ -227,6 +227,9 @@ class ApiClient(object):
         # data needs deserialization or returns HTTP data (deserialized) only
         if _preload_content or _return_http_data_only:
           response_type = response_types_map.get(str(response_data.status), None)
+          if not response_type and type(response_data.status) == int and 100 <= response_data.status <= 599:
+              # if not found, look for '1XX', '2XX', etc.
+              response_type = response_types_map.get(str(response_data.status)[0] + "XX", None)
 
           if response_type == "bytearray":
               response_data.data = response_data.data
diff --git a/samples/openapi3/client/petstore/python/petstore_api/api_client.py b/samples/openapi3/client/petstore/python/petstore_api/api_client.py
index 4096fc43c20..9fbad9a8d76 100755
--- a/samples/openapi3/client/petstore/python/petstore_api/api_client.py
+++ b/samples/openapi3/client/petstore/python/petstore_api/api_client.py
@@ -226,6 +226,9 @@ class ApiClient(object):
         # data needs deserialization or returns HTTP data (deserialized) only
         if _preload_content or _return_http_data_only:
           response_type = response_types_map.get(str(response_data.status), None)
+          if not response_type and type(response_data.status) == int and 100 <= response_data.status <= 599:
+              # if not found, look for '1XX', '2XX', etc.
+              response_type = response_types_map.get(str(response_data.status)[0] + "XX", None)
 
           if response_type == "bytearray":
               response_data.data = response_data.data